PHM and Medicus Mundi International commends the Global Action Plan (GAP) for highlighting the misuse and overuse of antimicrobial medicines in humans and animals, however, the document is weak in relation to regulation and accountability mechanisms. PHM and MMI urge WHO to support health systems strengthening to ensure appropriate use of anti-microbials and supproting the regulation of the marketing and use of antibiotics. Mandatory provisions will be needed to ensure adequate surveillance of antibiotic use in human and veterinary medicine and livestock production.